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KMID : 1144820180240020130
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대한의생명과학회지
2018 Volume.24 No. 2 p.130 ~ p.133
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Assessment of the Cardioprotection Offered by Fisetin in H2O2-induced Zebrafish (Danio rerio)-Tg (cmlc2: egfp)
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Lee Jeong-Soo
Park Eun-Seok
Kim In-Sik
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Abstract
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The aim of this study was to evaluate the protective function of fisetin, a natural flavonoid in zebrafish heart for the treatment of myocardial infarction in coronary and ischemic heart disease. For this purpose, we induced oxidative stress zebrafish (Danio rerio)-Tg (cmlc2: egfp) by H2O2 and then administered fisetin, the protective effect of fisetin was determined by measuring the heart rate following fisetin administration. After testing the toxicity of fisetin, we found that the heartt increased in a concentration-dependent manner, however there was no difference between the heart rates of embryos and adults. The improved heart rate demonstrated the cardioprotective effect of fisetin. The result showed that fisetin, at concentration of 3and 5 μM, significantly increased heart rate compared with the heart with H2O2 alone. This indicates that fisetin plays an important role in the prevention of heart damage and treatment of cardiovascular diseases caused by oxidative stress due to ischemia / reperfusion.
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KEYWORD
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Fisetin, Zebrafish (Danio rerio)-Tg (cmlc2: egfp), Cardiovascular disease, H2O2
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